A packed audience watches presentations for the Innovation Fund Finals event at Polsky Exchange North Wednesday, May 31. (Photo by Joe Sterbenc)

 

The AVnovum team presents their final pitch to IF’s Advisory Board. (Photo by Joe Sterbenc)

A month of Innovation Fest events celebrating UChicago breakthroughs in science, entrepreneurship, and more in the Windy City and around the world has come to a close with almost $1 million awarded to the winners of two prominent university startup competitions.

The University of Chicago Innovation Fund committee announced Monday that they will invest a total of $500,000 in three UChicago science startups— AVnovum, ClostraBio, and SwitchedSource — after the companies competed for capital in front of an audience of about 200 spectators May 31. Judges also awarded ClostraBio and SwitchedSource funding as part of the Edward L. Kaplan, ’71, New Venture Challenge (NVC). The NVC competition awarded a pool of $400,000 to its 11 startup finalists June 1.

“Researchers are looking beyond their discoveries to see their research save lives or solve a problem in the outside marketplace,” said John Flavin, UChicago Associate Vice President of Entrepreneurship and Innovation and head of the Polsky Center for Entrepreneurship and Innovation. “We’re enabling our faculty and students to go from idea to impact.”

Since it was founded in 2010, the Innovation Fund has awarded nearly $5.5 million to 65 startup ventures, and the 21st annual NVC is one of the top-ranked accelerator programs in the country. Both are part of UChicago Innovation Fest, a month-long spring festival led by UChicago’s top innovation leaders, including the Polsky Center for Entrepreneurship and Innovation, the Institute for Translational Medicine (ITM), the Rustandy Center for Social Sector Innovation at Chicago Booth, and the Office Research, Innovation and National Laboratories.

ITM investigators are part of the AVnovum team, which received $150,000 from the IF finals, and ClostraBio, which received a total of $290,000 from the IF and NVC finals. The scientists behind AVnovum and the other startups – ClostraBio and SwitchedSource – transformed their research into startups with the help of the Polsky Center’s Tech Commercialization team.

AVnovum tackles fungal infections in people with an impaired immune system. While current treatments often lead to liver toxicity or resistance to medicine, AVnovum’s AVpeptides act like tiny antibiotics, preventing good fungi in the microbiome – the trillions of microorganisms that live in our gut – from going bad.

“The gut microbiome is the forgotten organ of our body,” said Eugene Chang, MD, ITM investigator and AVnovum’s chief medical and co-chief scientific officer. “If you wipe it out with antibiotics, you get all kinds of diseases. The microbiome is so vital and interlinked with our own biology.”

AvNovum helps keeps the healthy microbes healthy and prevents infections, which could better help patients with diabetes or compromised immune systems. Its team includes Katherine Harris, PhD, Myles Minter, PhD, and Joseph Pierre, PhD.

ClostraBio’s team pitches their startup. (Photo by Joe Sterbenc)

ClostraBio is tackling food allergies by harnessing the power of the microbiome to create the first drugs to treat the disease and prevent life-threatening allergic reactions to triggers like peanuts.  The team includes ITM investigator Cathy Nagler, PhD, Jeff Hubbell, PhD, and John Colson, PhD.

“ClostraBio is solving this problem by creating new medicines that could actually stop the allergic reaction before it has a chance to start,” said Colson, ClostraBio’s director of operations. “This treatment is groundbreaking because it actually blocks the allergen from entering the bloodstream by targeting the intestinal barrier to boost its protective ability.”

Two of the companies, ClostraBio and AVnovum, which received financial investment from the Innovation Fund and the NVC  are part of a wave of groundbreaking microbiome developments at the University of Chicago and come just two weeks after The Duchossois Family Foundation announced a $100 million gift to establish The Duchossois Family Institute at the University of Chicago Medicine that will combine genetics, immunology, microbiome, and big data to create a “new science of wellness.”

“The microbiome plays a significant role in maintaining human well-being and in environmental health, and we are just starting to understand the full scope of its importance,” said Matt Martin, PhD, Polsky Center Assistant Director of Technology Commercialization and Licensing. “This has driven a surge of interest from commercial partners, and we have the opportunity to connect those partners with UChicago’s research strength in the microbiome.”

Switched Source delivers their final presentation. (Photo by Joe Sterbenc)

In addition to ClostraBio, startup SwitchedSource took home cash prizes in both competitions, receiving a combined $230,000 from the IF and NVC competitions. Presented by Charles Murray, PE, and Lane Nelson, a Chicago Booth student, SwitchedSource is a startup that offers a more efficient alternative for electricity providers. Their hardware device allows utilities to distribute power more reliably and , while also increasing the potential for renewable energy.

“Utilities can dictate exactly the direction and magnitude of power flow they want through this switch,” said Murray, founder and president of SwitchedSource. “Utilities don’t have flexible control out on the grid without our device.

Esya’s Yamuna Krishnan, PhD, pitches cell-scanning technology. (Photo by Joe Sterbenc)

Esya and O2M Technologies also competed in the IF finals last week. Esya is a platform that uses a breakthrough cell-imaging technology to better diagnose rare diseases, andO2M is developing a new imaging device that allows for safer cancer radiation treatment using oxygen mapping of tumors. Current treatments can cause side effects like tissue damage, skin problems, and more.

There was standing room only at the IF and NVC finals, and audience members said the startups deserved their top slots.

The O2M team presents their technology. (Photo by Joe Sterbenc)

“I was impressed with the high-caliber individuals that presented,” said Ed Drower, IF audience member and clinical project director at Medline. “I think the selection of finalists were all really stellar; there wasn’t a bad pitch in the whole group.”

 

Others were excited about the commercialization potential of the research presented.

“I think this is a good starting point for scientists to initiate their technologies,” said Sindhu Rajan, IF audience member and founder and CEO of Prana Diabetes. “This is how technology should be translated.”

For a complete list of competitors and award winners, click here for IF and here for NVC.

Learn more about UChicago Innovation Fest and the month-long global event lineup here, and enjoy videos from the 2017 kick-off event highlighting breakthrough research and its real-world impacts on everything from Alzheimer’s to cancer.

Innovation Fest Talks –  Critical Translation: From Science to Solutions

 

UChicago Innovation Fest is a month-long celebration of entrepreneurship and discovery around the University of Chicago that explores solutions to big problems, brainstorms ways to scale impact, and connects with leaders in business, science, healthcare, tech, and more. The annual festival is led by UChicago’s top leaders in innovation, including the Polsky Center for Entrepreneurship and Innovation, the Institute for Translational Medicine (ITM), the Rustandy Center for Social Sector Innovation at Chicago Booth, and the Office Research, Innovation and National Laboratories. Innovation Fest 2017 was sponsored by the University of Chicago Graham School of Continuing Liberal and Professional Studies.

By: Kathleen Ferraro/UChicago ITM